Laboratory of Neural and Neuroendocrine Regulations

Prof. Michael Ugrumov, PhD, MD

Head of the Department of Molecular Neurobiology at the Shemyakin – Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences (RAS);

Head of Laboratory of Neural and Neuroendocrine Regulations at the Koltzov Institute of Developmental Biology of RAS, Moscow, Russia

President of the Russian Society for Neurochemistry

E-mail:
michael.ugrumov@mail.ru

Memberships:‍ ‍

Russian Academy of Sciences
European Academy of Sciences and Arts
Serbian Academy of Sciences
French Academy of Pharmacy

American Society for Neurosciences
European Endocrine Society
European Society for Neuroendocrinology
European College of Neuropsychopharmacology
International Brain Research Organization

Ugrumov – Former: Advisor to the President of the RAS and the Ministry of Education and Science of the Russian Federation for International Cooperation;

Head of the Department for Multilateral Scientific Cooperation at the Presidium of RAS;

Coordinator of the Brain Research Program at the Presidium of RAS;

Vice President of the Russian Physiological Society;

Professor of the Faculty of Psychology at the National Research University Higher School of Economics (Moscow)

Awards:

National Order of Merit of the French Republic
Award of the Federation of American Societies for Experimental Biology
Russian Academy of Engineering Medal of Ivan Fedorov, the First Printer
Russian Academy of Sciences I.P. Pavlov Gold Medal
Russian Academy of Sciences I.M. Sechenov Gold Medal
CIS Physiological Societies Union Gold Medal of P.G. Kostyuk
Russian Academy of Sciences and Moscow State Univercity Medal "In Memory of Academician N.M. Emanuel"
Russian Physiologists Society L.A. Orbeli Award
Russian Federation II-nd degree Medal of Order "For Merit to the Fatherland"

Prof. Ugrumov was nominated as a visiting Professor and has conducted research and taught at:the Tokushima University Medical School (Japan), SUNY Upstate Medical University (Syracuse, USA), University P. et M. Curie (Paris, France), University Medical School of Ulm (Germany), University of Turin (Turin, Italy), and University of Tours Francois Rabelais (Tour, France).

Prof. Ugrumov graduated fromthe University Medical School (Moscow), got PhD at the Institute of Evolutionary Physiology and Biochemistry RAS (St. Petersburg) and Professorship at the Institute of Developmental Biology and the University Medical School (Moscow).

Prof. Ugrumov is the author of five monographs and more than 250 articles published in international high-ranking journals, as well as a supervisor of more than 40 PhD theses, including European ones.

Prof. Ugrumov made significant contribution:

(i) to the study of the role of neuroendocrine regulations in the development of the brain and the entire organism during ontogenesis, both in health and disease;

(ii) to the development of a methodology for the early diagnosis and preventive treatment of neurodegenerative diseases, primarily Parkinson's disease;

(iii) to the study of non-monoaminergic neurons that partially express a monoaminergic phenotype;

(iv) to the development of a concept for the adaptation of fundamental academic science in the post-Soviet space during the transition from a planned to a market economy.

Main interests: Developmental neurobiology, Neuroendocrinology, Neurodegenerative diseases with focus on the development of preclinical diagnosis and preventive neuroprotective therapy of Parkinson’s disease, International scientific cooperation.

Selected articles (2017 - 2026)

Pronina TS, Troshev DV, Kolacheva AA, Bogdanov VV, Ugrumov MV. (2026) Evidence that tyrosine hydroxylase does not have enzymatic activity in neurons of the supraoptic nucleus. Front Endocrinol (Lausanne). 17:1777453. doi: 10.3389/fendo.2026.1777453.

Bannikova AE, Pronina TS, Troshev DV, Bogdanov VV, Kolacheva AA, Pavlova EN, Blokhin VE, Kalashnikova VI, Ugrumov MV. (2026) Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice. PLoS One. 6;21(2):e0340281. doi:10.1371/journal.pone.0340281.

Ugrumov MV. (2024) Hypothalamic neurons fully or partially expressing the dopaminergic phenotype: development, distribution, functioning and functional significance. A review. Front Neuroendocrinol. 75:101153. doi: 10.1016/j.yfrne.2024.101153.

Troshev D, Blokhin V, Ukrainskaya V, Kolacheva A, Ugrumov M. (2022) Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research. Front Mol Neurosci. 15:1020070. doi: 10.3389/fnmol.2022.1020070.

Kim A, Pavlova E, Kolacheva A, Bogdanov V, Dilmukhametova L, Blokhin V, Valuev L, Valuev I, Gorshkova M, Ugrumov M. (2022) Development of early diagnosis of Parkinson's disease on animal models based on the intranasal administration of α-methyl-p-tyrosine methyl ester in a gel system. Biomed Pharmacother. 150:112944. doi: 10.1016/j.biopha.2022.112944.

Ugrumov M. (2020) Development of early diagnosis of Parkinson's disease: Illusion or reality? CNS Neurosci Ther. 26(10):997-1009. doi: 10.1111/cns.13429.

Kim A, Nigmatullina R, Zalyalova Z, Soshnikova N, Krasnov A, Vorobyeva N, Georgieva S, Kudrin V, Narkevich V, Ugrumov M. (2019) Upgraded Methodology for the Development of Early Diagnosis of Parkinson's Disease Based on Searching Blood Markers in Patients and Experimental Models. Mol Neurobiol. 56(5):3437-3450. doi: 10.1007/s12035-018-1315-2.

Mingazov ER, Khakimova GR, Kozina EA, Medvedev AE, Buneeva OA, Bazyan AS, Ugrumov MV. (2018) MPTP Mouse Model of Preclinical and Clinical Parkinson's Disease as an Instrument for Translational Medicine. Mol Neurobiol. Apr;55(4):2991-3006. doi: 10.1007/s12035-017-0559-6.

Khakimova GR, Kozina EA, Kucheryanu VG, Ugrumov MV. (2017) Reversible Pharmacological Induction of Motor Symptoms in MPTP-Treated Mice at the Presymptomatic Stage of Parkinsonism: Potential Use for Early Diagnosis of Parkinson's Disease. Mol Neurobiol. 54(5):3618-3632. doi: 10.1007/s12035-016-9936-9.

Kozina EA, Kim AR, Kurina AY, Ugrumov MV. (2017) Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiol Dis. 98:108-121. doi: 10.1016/j.nbd.2016.12.005.